{"id":26,"date":"2025-10-27T10:13:23","date_gmt":"2025-10-27T07:13:23","guid":{"rendered":"https:\/\/labgentech.ru\/?page_id=26"},"modified":"2026-02-12T14:54:20","modified_gmt":"2026-02-12T11:54:20","slug":"megagrant-25-075-60608","status":"publish","type":"page","link":"https:\/\/labgentech.ru\/en\/genteh\/megagrant-25-075-60608\/","title":{"rendered":"Megagrant of the Ministry of Education and Science of the Russian Federation within the framework of the implementation of the Federal Scientific and Technical Program for the Development of Genetic Technologies for 2019-2030 \"Postgenomic technologies for poultry farming\" (No. 25-075-60608-1-0073-000129, 2025-2027)."},"content":{"rendered":"<h2 class=\"wp-block-heading\">Project objectives:<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u2013 Study of the genome, transcriptome and metagenome of chickens to identify new molecular markers with high potential for use to improve economically valuable traits.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2013 Investigation of the molecular mechanisms of embryonic hibernation of chicken embryos and artificial molting of chickens.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2013 Development of approaches to improving economically useful bird traits using genetic technologies, including multimix analysis and analysis of large genomic data.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2013 Development of an integrated approach for the characterization and systematic analysis of chicken herds for the effective organization of breeding and genetic programs in the Russian Federation, including the creation of new crosses.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2013 Development of databases of informative biomarkers of effective economically valuable traits of chickens and software products for in silico research.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Project objectives:<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u2013 Creation of a DNA and RNA biobank of chicken tissues with various phenotypic traits.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2013 Analysis of metadata databases on phenotypes and economically useful traits of chickens for the identification and subsequent genomic and postgenomic analysis of the most contrasting bird traits.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2013 Sequencing, de novo assembly and annotation of genomes of chicken breeds that will be used to create the Russian egg cross. Genomic and transcriptomic analysis of chickens with contrasting phenotypic traits. Search for informative biomarkers associated with economically useful traits of chickens based on genome and transcriptome sequencing.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2013 Identification of new genes involved in the formation of economically useful traits of chickens using combined genome-wide and transcriptomic studies. Identification of regulatory mechanisms related to artificial moulting of chickens. Transcriptomic studies of embryonic hibernation of chicken embryos and mechanisms of dose compensation in chickens.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2013 Analysis of the chicken metagenomic community as one of the factors influencing productive egg production.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><br><strong>\u0420\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u044b \u0437\u0430 2025 \u0433.<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0412 2025 \u0433\u043e\u0434\u0443 \u0434\u043b\u044f \u0432\u044b\u043f\u043e\u043b\u043d\u0435\u043d\u0438\u044f \u0440\u0430\u0431\u043e\u0442 \u043f\u043e \u043f\u0440\u043e\u0435\u043a\u0442\u0443 \u0441\u043e\u0437\u0434\u0430\u043d\u0430 \u043d\u0430\u0443\u0447\u043d\u0430\u044f \u0433\u0440\u0443\u043f\u043f\u0430 \u00ab\u0418\u043d\u0442\u0435\u043b\u043b\u0435\u043a\u0442\u0443\u0430\u043b\u044c\u043d\u0430\u044f \u0433\u0435\u043d\u043e\u043c\u0438\u043a\u0430\u00bb \u0432 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\u0434\u043b\u044f \u043c\u0430\u0441\u0448\u0442\u0430\u0431\u043d\u044b\u0445 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0439.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0412 \u0440\u0430\u043c\u043a\u0430\u0445 \u0440\u0435\u0430\u043b\u0438\u0437\u0430\u0446\u0438\u0438 \u043f\u0440\u043e\u0435\u043a\u0442\u0430 \u0432 2025 \u0433. \u043f\u0440\u043e\u0432\u0435\u0434\u0435\u043d \u0440\u044f\u0434 \u043c\u0435\u0440\u043e\u043f\u0440\u0438\u044f\u0442\u0438\u0439, \u043d\u0430\u043f\u0440\u0430\u0432\u043b\u0435\u043d\u043d\u044b\u0445 \u043d\u0430 \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u0435 \u043a\u0430\u0434\u0440\u043e\u0432\u043e\u0433\u043e \u043f\u043e\u0442\u0435\u043d\u0446\u0438\u0430\u043b\u0430: \u0440\u0430\u0437\u0440\u0430\u0431\u043e\u0442\u0430\u043d\u0430 \u0438 \u0440\u0435\u0430\u043b\u0438\u0437\u043e\u0432\u0430\u043d\u0430 \u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u0442\u0435\u043b\u044c\u043d\u0430\u044f \u043f\u0440\u043e\u0433\u0440\u0430\u043c\u043c\u0430 \u0414\u041f\u041e \u00ab\u041c\u0435\u0442\u043e\u0434\u044b \u0431\u0438\u043e\u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0442\u0438\u043a\u0438 \u0432 \u0433\u0435\u043d\u043e\u043c\u0438\u043a\u0435 \u0438 \u0442\u0440\u0430\u043d\u0441\u043a\u0440\u0438\u043f\u0442\u043e\u043c\u0438\u043a\u0435\u00bb, \u043f\u0440\u043e\u0432\u0435\u0434\u0435\u043d\u044b \u0412\u0441\u0435\u0440\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u0430\u044f \u0448\u043a\u043e\u043b\u0430 \u043c\u043e\u043b\u043e\u0434\u044b\u0445 \u0443\u0447\u0451\u043d\u044b\u0445 \u0441 \u043c\u0435\u0436\u0434\u0443\u043d\u0430\u0440\u043e\u0434\u043d\u044b\u043c \u0443\u0447\u0430\u0441\u0442\u0438\u0435\u043c \u00ab\u0413\u0435\u043d\u043e\u043c\u043d\u044b\u0435 \u0438 \u043f\u043e\u0441\u0442\u0433\u0435\u043d\u043e\u043c\u043d\u044b\u0435 \u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0438 \u0432 \u0436\u0438\u0432\u043e\u0442\u043d\u043e\u0432\u043e\u0434\u0441\u0442\u0432\u0435\u00bb, \u0430 \u0442\u0430\u043a\u0436\u0435 \u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u0442\u0435\u043b\u044c\u043d\u044b\u0435 \u043c\u0435\u0440\u043e\u043f\u0440\u0438\u044f\u0442\u0438\u044f \u0434\u043b\u044f \u0448\u043a\u043e\u043b\u044c\u043d\u0438\u043a\u043e\u0432 \u0438 \u0441\u0442\u0443\u0434\u0435\u043d\u0442\u043e\u0432. \u0427\u043b\u0435\u043d\u044b \u043a\u043e\u043b\u043b\u0435\u043a\u0442\u0438\u0432\u0430 \u043f\u0440\u043e\u0435\u043a\u0442\u0430 \u043f\u0440\u043e\u0448\u043b\u0438 \u043a\u0443\u0440\u0441\u044b \u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0438, \u043f\u0440\u043e\u0444\u0435\u0441\u0441\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u043e\u0439 \u043f\u0435\u0440\u0435\u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0438 \u0438 \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u044f \u043a\u0432\u0430\u043b\u0438\u0444\u0438\u043a\u0430\u0446\u0438\u0438, \u0441\u0442\u0430\u0436\u0438\u0440\u043e\u0432\u043a\u0438 \u0432 \u0432\u0435\u0434\u0443\u0449\u0435\u043c \u043d\u0430\u0443\u0447\u043d\u043e-\u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u044c\u0441\u043a\u043e\u043c \u0438\u043d\u0441\u0442\u0438\u0442\u0443\u0442\u0435 \u0420\u0424.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><br><strong>Articles published in 2025<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">1. Gilyazova, I.; Korytina, G.; Kochetova, O.; Savelieva, O.; Mikhaylova, E.; Vershinina, Z.; Chumakova, A.; Markelov, V.; Abdeeva, G.; Karunas, A.; Khusnutdinova E. and Gusev O. Advances in Genomics and Postgenomics in Poultry Science: Current Achievements and Future Directions. Int. J. Mol. Sci. 2025, 26, 8285. <a href=\"https:\/\/doi.org\/10.3390\/ijms26178285\">https:\/\/doi.org\/10.3390\/ijms26178285<\/a> WOS Q1<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2. Kochetova, O.; Korytina, G.; Timasheva, Y.; Gilyazova, I.; Akhmetshin A.; Abdeeva, G.; Karunas, A. Khusnutdinova E. and Gusev O. Genomic Insights into Abdominal and Intramuscular Fat Deposition in Chickens and Their Implications for Productivity Traits: A Systematic Review. Animals. 2026 Volume 16, Issue 2, 260. <a href=\"https:\/\/doi.org\/10.3390\/ani16020260\">https:\/\/doi.org\/10.3390\/ani16020260<\/a> WOS Q1<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><br>3. Zamuner FT, Chan SS, Kessler MD, Vorontsov IE, Loginov A, Erbe R, Imada E, Xie DX, Guo T, Fertig EJ, Kulakovskiy IV, Danilova L, Favorov AV, Gaykalova DA. Epigenetic profiling reveals key super-enhancer networks driving oncogenesis in HPV-positive HNSCC. iScience. 2025 Oct 30;28(11):113911. <a href=\"https:\/\/doi.org\/10.1016\/j.isci.2025.113911\"><u>https:\/\/doi.org\/<\/u>10.1016\/j.isci.2025.113911<\/a>. PMID: 41323280; PMCID: PMC1266448. WOS Q1<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>\u0426\u0435\u043b\u0438 \u043f\u0440\u043e\u0435\u043a\u0442\u0430: \u2013 \u0418\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u0433\u0435\u043d\u043e\u043c\u0430, \u0442\u0440\u0430\u043d\u0441\u043a\u0440\u0438\u043f\u0442\u043e\u043c\u0430 \u0438 \u043c\u0435\u0442\u0430\u0433\u0435\u043d\u043e\u043c\u0430 \u043a\u0443\u0440 \u0434\u043b\u044f \u0438\u0434\u0435\u043d\u0442\u0438\u0444\u0438\u043a\u0430\u0446\u0438\u0438 \u043d\u043e\u0432\u044b\u0445 \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u044b\u0445 \u043c\u0430\u0440\u043a\u0435\u0440\u043e\u0432 \u0441 \u0432\u044b\u0441\u043e\u043a\u0438\u043c \u043f\u043e\u0442\u0435\u043d\u0446\u0438\u0430\u043b\u043e\u043c \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u0438\u044f \u0434\u043b\u044f \u0443\u043b\u0443\u0447\u0448\u0435\u043d\u0438\u044f [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"parent":176,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-26","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u041c\u0435\u0433\u0430\u0433\u0440\u0430\u043d\u0442 \u041c\u0438\u043d\u043e\u0431\u0440\u043d\u0430\u0443\u043a\u0438 \u0420\u043e\u0441\u0441\u0438\u0438 \u0432 \u0440\u0430\u043c\u043a\u0430\u0445 \u0440\u0435\u0430\u043b\u0438\u0437\u0430\u0446\u0438\u0438 \u0424\u0435\u0434\u0435\u0440\u0430\u043b\u044c\u043d\u043e\u0439 \u043d\u0430\u0443\u0447\u043d\u043e-\u0442\u0435\u0445\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u043f\u0440\u043e\u0433\u0440\u0430\u043c\u043c\u044b \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044f \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 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